Job Details

Working together toward limitless possibilities.

We are differentiated in the composition of our team, which includes individuals from all areas—science, technology, and business—who share apioneering mindset, and are passionate about finding better ways to create medicines for patients.

We seek diverse perspectives because we believe that engaging in candid, productive conflict around ideas is how we will push the boundaries of the possible.

Director, Protein Analytics and Biophysics

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 millionin funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees.

The Role:

Generate:Biomedicines is seeking a visionary and dynamic Director to lead our Protein Analytics and Biophysics function within the Therapeutic Assay Sciences Department, a critical pillar of our AI-driven drug discovery engine. This role offers a unique opportunity to shape the future of biotherapeutic innovation by guiding a multidisciplinary team at the forefront of analytical and biophysical characterization of therapeutic proteins and their molecular targets. The ideal candidate brings deep expertise in protein analytics and protein-protein interactions, coupled with exceptional leadership and a passion for advancing the frontiers of biologics development. As a strategic leader, you will chart the direction of the Biophysics group, mentor top-tier scientific talent, and collaborate cross-functionally across Therapeutic Assay Sciences, Protein Sciences, CMC/Tech-Ops, and Technology. Your team's output will power data-rich, high-resolution insights that feed directly into our machine learning feedback loops—accelerating design cycles and driving transformative impact across our therapeutic pipeline.

Here's how you will contribute:

• Lead and inspire a high-performing team pioneering advanced analytical and biophysical workflows, including HPLC/UPLC (SEC, RP, HIC, IEX), light scattering (SEC-MALS, DLS), thermal stability (DSF, DSC), CE-SDS, cIEF, LC/MS, SPR, BLI, and KinExA—delivering the molecular insights essential to next-generation biologics.
• Set the strategic vision for the Biophysics function, guiding the development of novel platforms and capabilities that align withGenerate's evolving therapeutic and technological priorities.
• Collaborate deeply withGenerate's Technology Organization to build seamless data pipelines and closed-loop automation systems that power real-time learning and optimization within ML-driven discovery cycles.
• Drive operational excellence by ensuring departmental goals are delivered with precision, managing capacity and prioritization while tracking progress against key performance indicators.
• Continuously evaluate and integrate emerging technologies to enhance the speed, depth, and fidelity of the Design-Build-Test loop—pushing the boundaries of biophysics-enabled drug design.
• Provide scientific and strategic leadership across the therapeutic pipeline, from early-stage molecular design through Candidate Selection and IND-enabling studies.
• Manage and optimize partnerships with CROs and external collaborators to scale capabilities and accelerate program timelines.
• Communicate impactfully with executive leadership and cross-functional stakeholders to align scientific strategy with company-wide objectives and innovation goals.

The Ideal Candidate will have:

• Ph.D. in a relevant scientific discipline (e.g., Biochemistry, Biophysics, Molecular Biology) or equivalent extensive post-bachelor's industry experience.
• 8+ years of progressive experience in the biopharma industry, with deep expertise in protein analytics, biophysics, and data-informed decision making.
• 5+ years of leadership experience, including direct management of cross-functional teams, other people managers, and senior-level scientists.
• Proven scientific creativity and rigor in solving complex protein characterization challenges across discovery and early development phases.
• Hands-on familiarity with lab automation platforms and high-throughput analytics to enhance scalability and efficiency of biophysical workflows.
• Exceptional communication and documentation skills, including experience drafting and reviewing regulatory submissions.
• Passion for integrating experimental data with machine learning models to accelerate therapeutic design and optimization.
• Track record of leading in complex, matrixed environments, with the ability to influence across scientific, technical, and organizational boundaries.
• Demonstrated success in advancing biologics from discovery through IND/Phase 1, with an understanding of both scientific and regulatory expectations.
• Inspirational team leader and mentor, committed to fostering excellence, inclusion, and professional growth across diverse teams.
• Strategic thinker with operational agility, capable of aligning scientific strategy with broader organizational objectives.

Location: Job will be based out of our Somerville, MA headquarters and requires a weekly onsite presence.

Generate:Biomedicines iscommitted to equal employment opportunityregardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range

$177,000 - $255,000 USD

Create a Job Alert

Interested in building your career at Generate Biomedicines? Get future opportunities sent straight to your email.

Apply for this job

*

indicates a required field

First Name *

Last Name *

Email *

Phone *

Resume/CV *

Enter manually

Accepted file types: pdf, doc, docx, txt, rtf

Enter manually

Accepted file types: pdf, doc, docx, txt, rtf

Education

School Select...

Degree * Select...

Address Line 1 *

Street address

Address Line 2 *

street address continued

City *

The city in which you reside

State * Select...

The State within the United States in which you reside

Postal Code *

Are you legally authorized to work in the United States? *

Do you now or will you in the future require sponsorship to work in the U.S.? (e.g., H-1B, O-1, OPT, etc)? * Select...

If you'll require the company to commence ("sponsor") an immigration or work permit case in order to employ you, either now or at some point in the future, then you should select Yes. Otherwise, select No.

Are you able to work in the specified job location, or if not local, are you willing to relocate for this position? * Select...

When are you able to start a new position? *

How did you hear about this job? * Select...

If other, please share source

LinkedIn Profile

Website

What geographical area do you live in? * Select...

Do you have at least 7+ years of progressive experience in the biopharma industry, with deep expertise in protein analytics, biophysics, and data-informed decision making? * Select...

Do you have 4+ years of leadership experience, including direct management of cross-functional teams, other people managers, and senior-level scientists? * Select...

Do you have hands-on familiarity with lab automation platforms and high-throughput analytics to enhance scalability and efficiency of biophysical workflows? * Select...

Demographic Questions

At Generate Biomedicines, we value belonging and believe in fostering an environment where a diversity of perspectives can thrive. This core value is a pillar of our business and critical to our success. Your responses will be used (in aggregate only) to help us identifyareas of improvement in our process. Your responseswill notbe associated with your specific application andwill not in any way be used in the hiring decision. Completion of the form is entirelyvoluntary.

How would you describe yourself as male, female, and/or transgender? (Select all that apply) Select...

Which of the following best represents how you think of yourself? (Select all that apply) Select...

How would you describe your race? (Select all that apply) Select...

Are you of Hispanic, Latino, or Spanish origin? Select...

Have you served on active duty in the U.S. Armed Forces, Reserves, or National Guard? Select...